Author/Editor		Čemažar, M; Menart, V; Gaberc-Porekar, V; Miklavčič, D; Serša, G
Title		Potentiation of anti-tumor effectiveness of electrochemotherapy by TNF-alpha on SA-1 tumors in mice
Type		članek
Source		In: Miklavčič D, Bajd T, Stanič U, editors. Proceedings of the 9th international conference on mechanics in medicine and biology; 1996 Jun 30-Jul 4; Ljubljana. Ljubljana: Slovenian society of medical and biological engineering,
Publication year		1996
Volume		str. 303-6
Language		eng
Abstract		Electrochemotherapy enables increased chemotherapeutic drug delivery into the tumors and tumor cells by application of short intense electric pulses at the tumor site. This therapy, that uses nonpermeant or poorly permeant chemotherapeutic drugs is very effective anti-tumor therapy leading into partial or complete regression of the tumors. To increase curability of the tumors new ways of adjuvant immunotherapy are sought. In this study adjuvant immunotherapy with tumor necrosis facotr alpha (TNF- alpha) was tested for its possible application in incrasing anti-tumor effectiveness of electrochemotherapy with bleomycin. Significantly prolonged tumor growth delay and increased tumor curability were observed after combination of TNF- alpha with electrochemotherapy with low doses of bleomycin. Therefore, the results of the study suggest that combination of electrochemotherapy with TNF- alpha may increase the curability of the tumors.
Descriptors		SARCOMA, EXPERIMENTAL DRUG THERAPY TUMOR NECROSIS FACTOR MICE ANIMALS, LABORATORY ELECTRIC STIMULATION THERAPY