Author/Editor		Uršič-Bratina, N; Keber, I; Kržišnik, C
Title		Dejavniki tveganja za aterosklerozo pri otrocih staršev s prezgodnjo koronarno boleznijo
Translated title		Atherosclerotic risk factors in children of parents with premature coronary heart disease
Type		članek
Source		Slov Pediatr
Vol. and No.		Letnik 3, št. 1-3
Publication year		1996
Volume		str. 77-81
Language		slo
Abstract		A family history of coronary heart disease predicts coronary risk in the next generation which is either the consequence of inherited traits or family aggregation of certain living habits. The aim of this study was to determine the differences between the children of parents with or without premature coronary artery disease. We compared the results of biochemical investigations and living habits in 2 groups of children: 57 children whose parents had myocardial infarction before the age of 45 (case group) and 57 children of the control group. 48 children in the case group and only 2 in the control group had a lipid modified diet, almost half of the children in both groups were physically inactive. There were only two smokers in the control group. One third of the children in both groups were overweight. The children in the case group had significantly higher values of diastolic blood pressure (83 +- 9.12 vs 73 +- 10.3 mm Hg, p < 0.001 ), of the waist - hip ratio (0.81 +- 0.06 vs 0.78 +- 0.06, p < 0.005), of LDL-cholesterol (2.73 +- 0.55 vs 2.45 +- 0,58 mmol/1, p < 0.01), of the ratio between CH and LDL-cholesterol (2.67 +- 0.7 vs 2,27 +- 0,74, p < 0.005), of glucose (4.8 +- 0.46 mmol/1 vs 4.5 +- 0.48 mmol/1, p < 0.005), borderline lower values of HDL cholesterol ( 1.2 +- 0.27 mmol/1 vs 1.3 +- 0.28 mmol/1, p < 0.08). In puberty Lp(a) was lower in girls than boys, due to the increase of Lp(a) values in boys and the decrease in girls. Children with lower values of birth weight have lower values of HDL cholesterol and higher values of triglycerides, and children with lower values of birth length had higher values of blood sugar and systolic blood pressure later in life. The present study has shown that children with a positive family history of premature coronary disease have a more atherogenic profile of some clinical and biochemical parameters than children without a positive family history.
Descriptors		ATHEROSCLEROSIS LIPOPROTEINS HYPERLIPIDEMIA CHILD CORONARY DISEASE