Author/Editor | Vrecl, M; Pogačnik, A; Lorger, J; Bavdek, SV | |
Title | Morphometric analysis of fetal rat lung after the administration of pyralene-3000 | |
Type | članek | |
Source | Pflugers Arch | |
Vol. and No. | Letnik 431, št. 6 Suppl 2 | |
Publication year | 1996 | |
Volume | str. 213-4 | |
Language | eng | |
Abstract | The effects of the application of commercial low chlorinated PCB Pyralene-3000 on rat lung development during late gestation were studied. In the developing lungs (17.5 to 21.5 days) the volume density (Vv) of a particular compartment and length density of potential air spaces (Lv) were determined. Significant difference (p<0.01) in epithelium to mesenchyme ratio (Epi/Mes) occurred between the control and treated groups on day 20.5 due to an increased volume proportion of mesenchyme (Vv/mes) in the treated group suggesting a small delay in maturation. Decreased volume proportion of potential airspaces (Vv/air) was observed on days 18.5 and 20.5. However, no differences were found on day 21.5 in any variables studied. | |
Descriptors | LUNG POLYCHLORINATED BIPHENYLS MATERNAL EXPOSURE BIOMETRY RATS ANIMALS, LABORATORY PREGNANCY, ANIMAL |