Author/Editor		Budihna, MV; Grebenc, H
Title		Racemic nicardipine and its (-) enantiomer dose-dependently inhibit intestinal absorption of digoxin in guinea-pig in vivo
Translated title		Racemni nikardipin in njegov (-) enantiomer od doze odvisno zavirata črevesno absorpcijo digoksina pri morskem prašičku in vivo
Type		članek
Source		Farm Vestn
Vol. and No.		Letnik 47, št. 2
Publication year		1996
Volume		str. 221-5
Language		eng
Abstract		In the study of interaction between digoxin and nicardipine we tried to establish whether the inhibition of digoxin intestinal absorption by nicardipine and its enantiomers was dose dependent. In previous studies in guinea-pig in vivo using (+-), (+), (-) nicardipine it has been found that the inhibition of digoxin intestinal absorption by nicardipine depended upon optical activity of nicardipine. In the present study the dose dependent inhibition of enteral absorption of digoxin by nicardipine and its (-) enantiomer was found. By extrapolation determined ICS50 was 0.27 mg/ml and 0.36 mg/ml (=0.027 mg/I00 g and 0.036 mg/100 g body weight) for (+-) and (-) nicardipine, respectively.
Descriptors		INTESTINAL ABSORPTION DIGOXIN NICARDIPINE STEREOISOMERS GUINEA PIGS ANIMALS, LABORATORY