Author/Editor		Tepeš, Bojan; Kavčič, Boris; Kragelj-Zaletel, Lijana; Gubina, Marija; Ihan, Alojz; Poljak, Mario; Križman, Igor
Title		Štiriletno prospektivno spremljanje histoloških sprememb želodčne sluznice po odstranitvi bakterije Helicobacter pylori
Translated title		Four year histological follow up of gastric mucosa after Helicobacter pylori eradication
Type		članek
Source		In: Cerar A, Križman I, editors. Gastritis in z njim povezane bolezni. 27. memorialni sestanek profesorja Janeza Plečnika. Ljubljana: Medicinska fakulteta, Inštitut za patologijo,
Publication year		1996
Volume		str. 102-12
Language		slo
Abstract		Backgraund. In the four year prospective study we wished to analyse reversibility of gastric mucosa inflammation after Helicobacter pylori (HP) eradication in chronic duaodenal ulcer (DU) patients. The second aim was evaluation of HP reinfection rates in Slovenia. Methods. We included 63 positive DU patients after successful eradication of HP in the period from 1990 to 1993. Patients were treated with tripe antibotic regime (colloidal bismuth subcitrate, amoxicillin and metronidazole) for at least 14 days. The criteria for HP eradication was complete absence of HP from four histological biopsies (two antral and two corporal) which were stained with hematoxylin-eosin and Warthin-Starry and negative culture from antum. The same diagnostic procedures were repeated at regular control upper GI endoscopies each year or whenever patients had upper GI difficulties. If patients were reinfected we performed RFLP analyses of urea B gene from paraffine embedded biopsies and from bacterial culture and Helico blot 2.0 test from patients serum for evaluation of anti cah A and anti vac A antibodies. Results. If HP eradication succeeded, we found disappearance of neutrophil granulocite infiltration two months after the beginning of antimicrobial therapy. Mononuclear cellular infiltration disappeared very slowly during three to four years. After three years we found residual lymphoid aggregates in 18.5% in antrum and in 7.4% in corpusl. After four years the percentage was 11.1 and 0 for residual lymphoid aggregates for the same regions respecitvely. We found also statisticaly significant reduction of antral atrophy during the first three years (might be a sampling bias). HP average reinfection rate in Slovenia was 1.74% and the same percentage of reinfection was also for Helicobacter heilmannii (H.h.). All HP reinfected patients had vas A and cag A antibodies but they did not develope any symptoms or endoscopical signs of DU recurrence during (abstract truncated at 2000 characters).
Descriptors		DUODENAL ULCER HELICOBACTER INFECTIONS HELICOBACTER PYLORI GASTRIC MUCOSA PROSPECTIVE STUDIES GASTRITIS GASTROSCOPY BIOPSY