Author/Editor		Kralj, E; Kavčič, B; Šramek-Zalter, S; Tepeš, B
Title		Patologija želodca v SB Celje v letu 1995 in ocena problema infekcije s Helicobacter pylori
Translated title		Gastric pathology in Celje general hospital in 1995 - estimation of Helicobacter pylori infection prevalence and its consequences
Type		članek
Source		In: Cerar A, Križman I, editors. Gastritis in z njim povezane bolezni. 27. memorialni sestanek profesorja Janeza Plečnika. Ljubljana: Medicinska fakulteta, Inštitut za patologijo,
Publication year		1996
Volume		str. 84-92
Language		slo
Abstract		Backgraund. Retrospective analysis of pathohistologic material at the Department for Pathomorphology, General Hospital Celje, and a critical consideration of proposed changes in diagnostic and therapy approach to gastritis and paptic ulcer disease. Patients and methods. The analysis involves available data and histology reports of 2046 abdominal biopsies carried out in five medical institutions during 1995. The study includes evaluation of the incidence of parituclar diseases and frequency of Helicobacter pylori (HP) infection within the selected diseases, efficiency of some therapeutic protocils, sensitivity of histology in the identification of HP and incidence of pre-neoplastic lesions and carcinomas. Results of the study illustrating the real praxis were contrasted to the findings from controlled studies found in literature, and an attempt was made to explain the disagreements. Results. HP infection was present in majority, but not all, duodenal (89,4%) and gastric (62,6%) ulcer patients. That stresses the need for identification of HP and argues against empiric therapy. Comparison of different therapeutic regimens proved acceptability of omeprayole/ amoxicillin/ tinidazole protocol in everyday praxis (eradication rate 86,2%). Urease test and histological identification of HP had similar sensitivities in our material. High frequency of gastric carcinoma in our series and cases of endoscopically unrecognised carcinomas are additional arguments for biopsy. Conclusion. Reduction of expenses related to the HP-infection related diseases is by all means feasible and necessary. Unselective imitation of foreign diagnostic and therapeutic models could provoke substantial negative consequences. Successful treatment may implement larger savings than the immediate reducation of therapy expenses. We propose that both the regional prevalence of HP infection and the prevalence ofg gastric carcinoma should become regulative criteria in (abstract truncated at 2000 characters).
Descriptors		PEPTIC ULCER GASTRITIS HELICOBACTER PYLORI BIOPSY GASTROSCOPY