Author/Editor		Maraspin, V; Cimperman, J; Lotrič-Furlan, S; Pleterski-Rigler, D; Strle, F
Title		Treatment of erythema migrans in pregnancy
Type		članek
Source		Clin Infect Dis
Vol. and No.		Letnik 22, št. 5
Publication year		1996
Volume		str. 788-93
Language		eng
Abstract		The course of the illness and the outcome of pregnancy were investigated in a prospective study of 58 consecutively enrolled pregnant women with typical erythema migrans at the University Medical Centre of Ljubljana, Slovenia. Thirteen patients (22.4%) acquired boorrelial infection in the first trimester of pregnancy, 27 (46.6%) in the second trimester, and 18 (31%) in the third trimester. All patients were treated for 14 days: 2 (3.4%) with phenoxymethylpenicillin (1 million IU thrice per day), 3 (5.2%) with bezylpenicillin (10 million units twice per day), and 53 (91.4%) with ceftriaxone (2 g daily). For 51 of the 58 women (87.9%), the pregnancies were normal and the infants were born at term, were clinically healthy, and had normal psychomotor development. Of the remaining 7 pregnancies, 1 ended with a missed abortion and 5 with preterm birth; 1 of the preterm babies had heart abnormalities. One child born at term was found to have urologic abnormalities at 7 month of age. A causal relationship between borrelial infection and fetal adverse effects has not been proved, and for at least some such cases a reasonable explanation (not associated with Lyme borreliosis) was found.
Descriptors		ERYTHEMA CHRONICUM MIGRANS ANTIBIOTICS PREGNANCY COMPLICATIONS, INFECTIOUS PREGNANCY ABORTION, MISSED CEFTRIAXONE CEPHALOSPORINS HEART DEFECTS, CONGENITAL INFANT, NEWBORN INFANT, PREMATURE PENICILLINS PREGNANCY OUTCOME URINARY TRACT