| Author/Editor | Gregorič, A; Kaplar-Vučevac, M | |
| Title | Primerjava učinkovitosti sekvencijske uporabe amoksicilina s klavulansko kislino in cefuroksima/cefuroksim-aksetila pri bakterijskih infekcijah pri otrocih | |
| Translated title | Comparative efficacy of sequential administration of amoxicillin/clavulanic acid combination versus cefuroxime/cefuroxime axetil in the treatment of bacterial infections in children | |
| Type | članek | |
| Source | Slov Pediatr | |
| Vol. and No. | Letnik 2, št. 4 | |
| Publication year | 1995 | |
| Volume | str. 17-20 | |
| Language | slo | |
| Abstract | Background. The aim of the study was to compare the efficacy of sequential administration of amoxycillin/clavulanic acid combination (Amoksiklav) versus sequential cefuroxime/cefuroxime axetil in the treatment of hospitalized children with respiratory and urinary tract infections. Methods. A total of 75 patients included in an open, controlled clinical trial were randomly allocated to receive either the study or the control drug. All children included in the study were treated for serious urinary or respiiratory tract infections in the Pediatrics Department of the Maribor General Hospital. The study groups included 38 children, 26 girls and 12 boys, with a mean age of 6.22 years. The control group included 37 children, 22 girls and 15 boys, with a mean age of 6.15 years. After random allocation, the distribution of patients in the study/control group according to indication was 19/24 wiith bronchopneumonia, 14/7 with pyelonephritis and 6/6 with chronic recurrent urinary tract infections. Results. The therapeutic effect was assessed as very good and good in 100% of patients in both groups. In the Amoksiklav-treated group mild side effects were observed in two children (local pain after IU injection in one, and malaise in another child). Conslusions. Sequential administration of the amoxycillin/clavulanic acid combination (Amoksiklav) and cefuroxime/cefuroxime axetil proved to be highly efficacious in the treatment of serious respiratory and urinary tract infections in pediatric patients. In additionn to efficacy, such a regiment is also very cost-effective since it allows earlier discharge from hospital. | |
| Descriptors | AMOXICILLIN CLAVULANIC ACIDS CEFUROXIME RESPIRATORY TRACT INFECTIONS URINARY TRACT INFECTIONS |