Author/Editor		Poljak, M; Gale, N; Kambič, V; Ferluga, D; Fischinger, J
Title		Overexpression of p53 protein in benign and malignant laryngeal epithelial lesions
Type		članek
Source		Anticancer Res
Vol. and No.		Letnik 16, št. 4A
Publication year		1996
Volume		str. 1947-51
Language		eng
Abstract		This study investigated the immunohistochemical expression of p53 protein in various laryngeal lesions using Kambic's classification from simple hyperplasia to invasive squamous cell carcinoma (SCC), and analyzed the relationship between p53 protein overexpression and the severity of epithelial abnormalities, p53 overexpression wwas observed in 10/19 (53%), in 9/16 (56%), and in 9/13 (69%) case of simple, abnormal, and atypical lyperplasia respectively, and also in 8/ž0 (80%) cases of SCC. The proportion of immunoreactive cells and staining intensity increased with the progression of the epithelial hyperplastic lesions. Our study confirms tne association of p53 protein overxpression with laryngeal epithelial hyperplastic lesions which have the potential to transform into malignancy, but considering the follow-up of the patients, p53 expression cannot be considered a reliable progrnostic factor for any group of laryngeal epithelial hyperplastic lesions regardless of the severity of the lesions.
Descriptors		LARYNGEAL NEOPLASMS LARYNX PROTEIN P53 RETROSPECTIVE STUDIES IMMUNOCHEMISTRY TUMOR MARKERS, BIOLOGICAL HYPERPLASIA EPITHELIUM