| Author/Editor | Janša, R; Preželj, J; Kocijančič, A; Osredkar, J; Ferlič, F | |
| Title | Androstanediol glucuronide in patients with pancreatic cancer and in those with chronic pancreatitis | |
| Type | članek | |
| Source | Horm Metab Res | |
| Vol. and No. | Letnik 28, št. 8 | |
| Publication year | 1996 | |
| Volume | str. 381-3 | |
| Language | eng | |
| Abstract | The differential diagnosis between pancratic cancer and chronic pancreatitis is extremely difficult. Beside CA19-9 level determinations, many tests have been tried with the aim to facilitate this distinction. Serum androgen levels have been used for this purpose. To further explore the value of androgen markers in differentiating pancratic cancer from chronic pancratitis we determined the serum levels of androstanediol glucuronide and of adrogens in the two groups of patients and compared them with CA19-9 levels. A total of 25 males were entered into the study. of these, 13 patients had pancreatic cancer and 12 chronic pancreatitis. They were comparable as to their body weight and age. patients with pancreatic cancer had significantly lower serum testosterone, dihydrotestosterone and androstanediol glucuronied levels, but testosterone/dihydrotestosterone rations when compared to patients with chronic pancreatitis. Only androstanediol glucuronide and dihydrotestosterone serum concentrations had such a small overlap between the two groups that could be used for differentiation, their sensitivity and specificity being comparable to those of CA19-9 levels. The present study has shown for the first time that serum androstanediol glucuronide levels in male patients with pancreatic cancer are significantly lower than in those patients with chronic pancreatitis. Furthermore, the sensitivity and specificity of serum andorstanediol glucuronide levels which can be used to differentiate between pancreatic cancer and chronic pancratitis are comparable to those of CA19-9. | |
| Descriptors | PANCREATIC NEOPLASMS PANCREATITIS GLUCURONATES ANDROSTANES CA-19-9 ANTIGEN AGED MIDDLE AGE STANOLONE TESTOSTERONE DIAGNOSIS, DIFFERENTIAL ANDROGENS |