Author/Editor		Urbančič, A; Buturović-Ponikvar, J; Ponikvar, R; Bren, AF; Kveder, R
Title		Hemodiafiltration with AN69 dialyser membrane is an effective method for beta-2-microglobulin removal from uremics
Translated title		Hemodijafiltracija s pomoću AN69 dijalizatorske membrane djelotvorna je metoda za odstranjivanje beta-2-mikroblobulina u uremičara
Type		članek
Source		Liječ Vjesn
Vol. and No.		Letnik 118, št. Suppl 2
Publication year		1996
Volume		str. 132-5
Language		eng
Abstract		In our clinical study the effectiveness of hemodiafiltration with AN 69 dialvser in beta-2-microglobulin removal in uremics was evaluated. Standard hemodiafiltration procedure (acetate bath 500 ml/min, 36 degrees C, 3 l of postdilutional bicarbonate infusion solution Biosol 40, Hospal; and blood flow 300 ml/min) was compared to hemodiafiltration modalities using blood flow 200 ml/min, dialyzate temperature 38.5 degrees C and infusion solution 0.9% NaCI (saline). Eight chronic dialysis pts participated in the study. RIA method was used for teba-2-microglobulin determination. Absorbed, dialysed and total removed beta-2-microglobulin were calculated. The study has shown that hemodiafiltration with AN 69 dialyser membrane is an effective method for beta-2-microglobulin removal in uremics. Both adsorption of beta-2-microglobulin on AN69 dialyser membrane and filtration through it were important elimination processes. The total beta-2-microglobulin removed was 195 to 330 mg per hemodiafiltration session, which is as much as daily beta-2-microglobulin production. So it seems reasonable to assume that long-term replacement therapy using high efficiency procedure and biocompatible and permeable dialyser membranecould at least postopone the occurrence of simptoms of dialysis-related amyloidosis.
Descriptors		UREMIA HEMODIAFILTRATION BETA 2-MICROGLOBULIN KIDNEY FAILURE, CHRONIC ACRYLONITRILE MEMBRANES, ARTIFICIAL ADULT