Author/Editor		Matko, Ivan
Title		Akutni pancreatitis
Translated title		Acute pancreatitis
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 35, št. 2
Publication year		1996
Volume		str. 221-41
Language		slo
Abstract		Regardless of its etiology, acute pancreatitis is a severe, even life-threatening disease. The etiologic agents in patients with acute pacreatitis are generally known, yet the exact pathogenetic mechanisms, which trigger activation of pancreatic enzymes within pancreas, and are crucial to the course of the disease, are still unclear. Etiologic treatment of the disease has not yet been defined. The present therapy therefore emphasises supportive measures and aims to maintain the patient's vital functions and control complications. In patients with acute gallstone pancreatitis and other conditions causing obstruction to the flow of bile and pancreatic secretion into the duodenum, outstanding results have been obtained by new interventional techniques and modern imaging studies. The same applies to all life-threatening complications of acute pancreatitis. These novel treatment modalities have markedly reduced the range of indications for emergency surgery in patients with acute pancreatitis. New percutaneous and endoscopic interventional techniques, as well as new forms of medical treatment are being developed.
Summary		Akutni pankreatitis je ne glede na etiologijo huda, življenje ogrožajoča bolezen. Etiološki prožilci bolezni so zvečine znani. Slabše raziskano je patogenetsko dogajanje, ki sproži dejavnost encimov trebušne slinavke v samem organu, kar je za klinični potek bolezni odločilno. Etiološko zdravljenje še vedno ni znano. Zdravilna prizadevanja so zato usmerjena k splošni podpori organizmu za vzdrževanje temeljnih življenjskih funkcij in k zdravljenju zapletov. Pri biliarnem akutnem pankreatitisu in stanjih, ki zavirajo odtok žolča in izločkov trebušne slinavke v dvanajstnik, so interventni posegi ob sodobnih slikovnih tehnikah dosegli pomembne uspehe. Isto velja za življenje ogrožujoče lokalne zaplete akutnega pankretitisa. S tem so se zmanjšale indikacije za nujne kirurkške posege pri zdravljenju akutnega pankreatitisa in njegovih zapletov. Nove možnosti interventnega zdravljenja s perkutanimi in endoskopskimi metodami in tudi nove metode zdravljenja z zdravili so v razvoju.
Descriptors		PANCREATITIS ACUTE DISEASE