Author/Editor		Paragi, Metka; Kraigher, Alenka; Čižman, Milan; Gubina, Marija; et al, ;
Title		Razširjenost serotipov pri invazivnih obolenjih, ki jih pri otrocih v Sloveniji povzročajo Haemophilus influenzae, Neisseria meningitidis in Streptococcus pneumoniae
Translated title		Spreading of serotypes in invasive diseases caused by Haemophilus influenzae, Neisseria meningitidis and Streptococcus pneumoniae in children in Slovenia
Type		članek
Source		Zdrav Vars
Vol. and No.		Letnik 36, št. 3-4
Publication year		1997
Volume		str. 76-81
Language		slo
Abstract		Capsulated bacteria as are Haemophilus influenzae, Neisseria meningitidis and Streptococcus pneumoniae are the main causative agents of invasive infections in children. Protective immunisation could for a longer period protect children against these serious diseases with possible permanent consequences and an increasing prevalence of resistant strains. For this purpose, study was performed which involved all the children aged from 0 to 14 years in the period 1993 - 95 from whose sterile body fluids the mentioned three bacteria were isolated. The most frequent serotypes/serogroups were: in Hi type b, in Nm type B and in Stp types 14, 19, 23, 6, 4, 18 and 7. Mostly children in the age from 0 to 1 year fell ill, with greatest number of cases caused by Hi, followed by Nm and Stp. Average incidence was 12,4:5,07 in Hi; 4,43 in Stp and 2,90 in Nm. Mortality due to invasive infection was the same for Hi and Stp (0,18) and half of this number for Nm.
Summary		Kapsulirane bakterije, kot so Haemophilus influenzae, Neisseria meningitis in Streptococcus pneumoniae, so glavni povzročitelji invazivnih okužb pri otrocih. Ker so te bolezni resne, obenem pa narašča prevalenca rezistentnih sevov, zaradi česar so možne trajne posledice, bi zaščitno cepljenje lahko ščitilo otroke daljše obdobje. V ta namen je bila narejena študija, ki je zajemala vse otroke, ki so bili v obdobju 1993-95 stari od 0 do 14 let in so bile iz njihovih sterilnih telesnih tekočin izolirane omenjene tri bakterije. Najpogostejši serotipi/seroskupine so bili pri Hi tip B, pri Nm tip B in pri Stp tipi 14, 19, 23, 6, 4, 18 in 7. Zbolevali so največ otroci v starosti od 0 do 1 leta z največjim številom obolenj, ki jih je povzročil Hi, tej sta sledili Nm in Stp. Povprečna incidenca je bila 12,4, od tega 5,07 pri Hi; 4,43 pri Stp in 2,90 pri Nm. Umrljivost po invazivnem obolenju je bila enaka pri Hi in Stp (0,18) in za polovico manjša pri Nm.
Descriptors		HAEMOPHILUS INFLUENZAE NEISSERIA MENINGITIDIS STREPTOCOCCUS PNEUMONIAE COMMUNICABLE DISEASE CONTROL INFANT, NEWBORN INFANT CHILD, PRESCHOOL CHILD ADOLESCENCE SLOVENIA VACCINES, CONJUGATE VACCINES, SYNTHETIC HAEMOPHILUS INFECTIONS MENINGOCOCCAL INFECTIONS STREPTOCOCCAL INFECTIONS