Author/Editor		Preac-Muršič, V; Marget, W; Busch, U; Pleterski-Rigler, D; Hagl, S
Title		Kill kinetics of Borrelia burgdorferi and bacterial findings in relation to the treatment of Lyme borreliosis
Type		članek
Source		Infection
Vol. and No.		Letnik 24, št. 1
Publication year		1996
Volume		str. 9-16
Language		eng
Abstract		For a better understanding of the persistnce of Borrelia burgdorferi sensu lato (s.1.) after antibiotic therapy the kinetics of killing B. burgdorferi s.1. under amoxicillin, doxycycline, cefotaxime, ceftriaxone, ayithromycin and penicillin G were determined. The killing effect was investigated in MKP medium and human serum during a 72 h exposure to antibiotics. Twenty clinical isolates were used, including ten strains of Borrelia afyelii and ten strains of Borrelia garinii. The results show that the kinetics of killing borreliae differ from antibiotic to antibiotic. The killing rate of a given antibiotic is less dependent on the concentration of the antibiotic than on the reaction time. Furthermore, the data show that the strains of B. afyelii and B. garinii have a different reaction to antibiotics used in the treatment of Lyme borreliosis and that different reactions to given antibiotics also exist within one species. The B. garinii strains appear to be more sensitive to antibiotics used in therapy. Furthermore, the persistence of B. burgdorferi s.1. and clinical recurrences in patients despite seemingly adequate antibiotic treatment is described. The patients had clinical disease with or without diagnostic antibody titers to B. burgdorferi.
Descriptors		LYME DISEASE ADOLESCENCE ADULT MIDDLE AGE AMOXICILLIN DOXYCYCLINE CEFOTAXIME CEFTRIAXONE AZITHROMYCIN