Author/Editor | Eberl-Gregorič, E; Filipič, B; Rozman, S; Cencič, A; Drinovec, B | |
Title | Porcine interferon-gamma inhibits the growth of Legionella pneumophila in WiREF cells in vitro | |
Type | članek | |
Source | Folia Microbiol (Praha) | |
Vol. and No. | Letnik 41, št. 4 | |
Publication year | 1996 | |
Volume | str. 309-14 | |
Language | eng | |
Abstract | The intracellular growth of Legionella in WiREF (Wistar rat embryonal fibroblast) cells was inhibited by porcine interferon-gamma. The effect was compared with that of different human interferons (alpha and gamma). The growth inhibition was dose-dependent and required the pretreatment of WiREF cells with interferon. The development of an antibacterial state of the cells was observed. When interferon was added together with bacteria or 1 d after the infection there was no inhibition. Also, there was no direct antibacterial effect of the interferon. In addition, cell pretreatment with a combination of interferon and antibiotics failed to show a synergistic effect. | |
Descriptors | LEGIONELLA PNEUMOPHILA INTERFERON TYPE II RATS FIBROBLASTS MICROSCOPY, ELECTRON |