Author/Editor		Orel, R; Wraber, B; Kotnik, V; Sedmak, M
Title		Serum soluble interleukin-2 receptor concentration before and after introduction of a gluten-free diet: possible parameter for evaluation of the therapeutic effect in children with coeliac disease
Translated title		Serumska koncentracija topnih receptorjev za interlevkin-2 pred uvedbo in po uvedbi brezglutenske diete: možen parameter za ocenjevanje terapevtskega uspeha pri otrocih s celiakijo
Type		članek
Source		Slov Pediatr
Vol. and No.		, št. 4
Publication year		1996
Volume		str. 8-11
Language		eng
Abstract		We measured the serum soluble interleukin-2 receptor (sIL-2R) concentrations before and one month after the introduction of a gluten-free diet in 12 children with newly diagnosed coeliac disease. We found significant differences in sIL-2R levels before and after treatment (p<0.005). Although large interindividual variations of sIL-2R concentrations were found between individuals and the individual values did not correlate with the severity of the clinical picture, the dynamics of the concentration fall, expressed as a pre/post treatment index, correlated with the dynamics of symptom regression and probably with the regression of inflammation in the gut. We also measured sIL-2R production after in vitro stimulation of peripheral blood mononuclear cells (MNC) from 16 coeliac patients and 20 controls with gluten antigens (fractions F III and B, respectively). No significant differences were found in stimulated vs.non-stimulated MNC cultures, so we concluded, that changes in sIL-2R concentrations observed in vivo were mainly due to a local intestinal immune response. We believe that measurement of pre and post-treatment serum sIL-2R levels in coeliac patients could be a useful guide to the success of treatment, including cases of silent, atypical coeliac diasease, in which clinical remission connot be followed by symptomatic relief.
Descriptors		CELIAC DISEASE RECEPTORS, INTERLEUKIN-2 GLUTEN INTERLEUKIN-2 DIETARY PROTEINS LEUKOCYTES, MONONUCLEAR