Author/Editor		Rakovec, S
Title		Antibiotska profilaksa u gastroduodenalnoj kirurgiji
Type		članek
Source		In: Digestivna kirurgija: mehanički šav, antibiotska profilaksa. ,
Publication year		1989
Volume		str. 103-7
Language		cro
Abstract		The presence of bacterial flora in the stomach depends mainly on gastric acidity. The normal stomach has no permanent bacterial colonization. It is present, however, in conditions associated with reduced acidity. These include chronic gastritis, tastric ulcer and gastric cancer. In a bleeding ulcer or gastric obstruction, the acidity may ne normal, but the gastric barrier is ineffective because of dilution. The permanent bacterial flora found in these conditions consists mainly of bacteria originating in the mouth and pharynx, where streptococci and staphylococci are the prevalent aerobes, while peptococci, the Bacteroides group, and Veillonella predominante among anaerobes. Often coliforms, especially E. coli, are found as well. Anaerobes prevail over aerobes in a ratio of 10:1. Thus prophylaxis in gastric and duodenal surgery is indicated in sub and anacidic conditions. In such cases numerous authors have demonstrated a significant decline of septic complications, achieving rates as low as 5%, compared to about 25% for control groups withoyt prophylaxis. At our Hospital, antibiotic prophylaxis was used in 70 sub - and anacidic patients in the past years. 38 patients received clindamycin, and two of them developed a postoperative infection. 32 patients were treated with cefotaxime, and inflammatory complications were again encountered in two cases. The drugs were administered in a single dose about 30 minutes before operation. So inflammatory complications were observed in four of the 70 patients receiving antibiotic prophylaxis (5.71%). In a control group of 75 patients without prophylaxis, undergoing surgery for the same conditions, postoperative infection occurred in fifteen cases (20,0%). The incidence of infectious complications in gastroduodenal surgery can be (according to this study) appreciably reduced bu proper antibiotic prophylaxis.
Descriptors		GASTROINTESTINAL DISEASES ANTIBIOTIC PROPHYLAXIS CLINDAMYCIN CEFOTAXIME STOMACH DISEASES