| Author/Editor | Weis, Serge; Protopapa, Despina; Hischa, Andrea; Winkler, Peter A; Reulen, Hans-Juergen; Mehraein, Parviz | |
| Title | Morphometric investigations of proliferation markers in recurrent meningiomas | |
| Type | članek | |
| Source | Acta Stereol | |
| Vol. and No. | Letnik 16, št. 1 | |
| Publication year | 1997 | |
| Volume | str. 75-80 | |
| Language | eng | |
| Abstract | The significance of proliferation markers in predicting recurrencies of meningiomas was investigated by means of immunohistochemistry and morphometry. Antibodies against PCNA (P10) and MIB-1 were used. The numerical density (ND) as well as the labelling index (LI) of immunopositive cells were determined. Meningotheliomatous meningiomas (GO) without recurrency, meningotheliomatous meningiomas which recurred and became meningotheliomatous meningiomas (G1), meningotheliomatous meningiomas which recurred and became anaplastic meningiomas (G2), and anaplastic meningiomas at first operation (G3) were investigated. The comparison of all determined parameters of the first operation between two groups (i.e. 0/1, 0/2, 0/3,1/2, 1/3, 2/3) showed that not in all cases the differences reached the level of statistical significance. In Group 1, in nearly 50% of the cases, a decrease or an increase of the PCNA-LI and PCNA-ND was observed in the material of the second operation as compared to the first intervention. In Group 1, nearly all the cases with one recurrency showed a decrease of the MIB1-LI and MIBl-ND in the material of the second operation as compared to the first intervention. In Group 1, in the cases with two recurrencies, a heterogeneous pattern of increased or decreased PCNA-LI, PCNA-ND, MIB1-LI, and MIB-ND was observed. In Group 2, the cases with one recurrency, showed with the exception of one case a significant increase of PCNA-LI, PCNA-ND, MIB1-LI, and MIB- ND. In Group 2, in the cases with two recurrencies, a heterogeneous pattern of decreased or increased PCNA-LI, PCNA-ND, MIB1-LI, and MIB-ND was observed between the tumor material of the different surgical interventions. Proliferation markers do not give significant information for predicting the potential of the tumor to recur. PCNA labelled more cells then MIB-1. (Abstract truncated at 2000 characters). | |
| Descriptors | MENINGIOMA PROLIFERATING CELL NUCLEAR ANTIGEN MENINGEAL NEOPLASMS NEOPLASM RECURRENCE, LOCAL |