Author/Editor		Battelino, Tadej; Goto, Masakatsu; Zeller, W Patrick
Title		Dexamethasone attenuates hypoglycemia in ten day old rats treated with TNF alpha
Type		članek
Source		Res Commun Mol Pathol Pharmacol
Vol. and No.		Letnik 92, št. 2
Publication year		1996
Volume		str. 149-54
Language		eng
Abstract		Hypoglycemia during septic shock is a common and life-threatening sign in the newborn. TNFalpha is an important cytokine in endotoxic shock. The present study was performed to investigate if TNFalpha induces hypoglycemia and if dexamethasone ameliorates the TNFalpha effects in 10 day old rats. TNFalpha induced hypoglycemia and lactacidemia without altering plasma insulin concentration in 10 day old rats. TNFalpha increased GLUT1 mRNA abundance in brain, liver, muscle and fatty tissue, and decreased liver phosphoenolpyruvate carboxykinase (PEPCK) mRNA abundance. Dexamethasone attenuated the hypoglycemia and lactacidemia. Dexamethasone blunted the increase of GLUT1 mRNA abundance and increased the liver PEPCK mRNA abundance. Dexamethasone may be beneficial by promoting gluconeogenesis.
Descriptors		HYPOGLYCEMIA DEXAMETHASONE TUMOR NECROSIS FACTOR SHOCK, SEPTIC RATS, SPRAGUE-DAWLEY ANIMALS, NEWBORN BLOOD GLUCOSE INSULIN LACTATES PHOSPHOENOLPYRUVATE CARBOXYLASE RNA, MESSENGER MONOSACCHARIDE TRANSPORT PROTEINS