Author/Editor		Colosimo, C; Albanese, A; Hughes, AJ; Sales de Bruin, VM; Lees, AJ
Title		Some specific clinical features differentiate multiple system atrophy from Parkinson's disease but not from Steele-Richardson-Olszewski syndrome
Translated title		Nekatere klinične značilnosti ločujejo multiplo sistemsko atrofijo od Parkinsove bolezni, ne pa od sindroma Steele-Richardson-Olszewski
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 65, št. Suppl 3
Publication year		1996
Volume		str. III-31-5
Language		eng
Abstract		Among all the consecutive cases of pathologically confirmed multiple system atrophy (MSA) collected in 8 years at the Parkinson's disease Society Brain Bank, the ones which had presented with a pure parkinsonian syndrome were retrospectively studied. Clinical features which were analyzed included: rapidity of disease progression, symmetrical onset of symptoms, absence of tremor at initial presentation, response to levodopa and the associated presence of autonomic dysfunction. Fourteen out of 16 patients were also studied with TC brain scan. The frequency of the selected items in MSA was compared to that of 20 pathologically confirmed cases of Parkinson's disease (PD) and of 16 pathologically confirmed cases of Steele-Richardson-Olszewski syndrome (SROS). It was found that a probability scale based on the 5 items selected, discriminates early stages of the pure parkinsonian forms of MSA from PD, but not from SROS. Patients affected by SROS, however, often presented additional clinical signs which helped to differentiate this clinical entity from PD.
Summary		Med vsemi primeri multiplih sistemskih atrofij (MSA), patološko potrjenimi v zadnjih osem letih pri Parkinson's disease Society Brain Bank, smo izbrali le tiste s čistim parkinsonizmom. Retrospektivno smo preučili klinične značilnosti: hitrost napredovanja bolezni, simetrijo začetnih simptomov, tremor ob začetku bolezni, odzivnosti na levodopo in pridruženost avtonomnih motenj. Pri 14 od 16 bolnikov je bila opravljena tudi CT možganov. Opazovali smo značilnosti pri 20 patološko potrjenih primerih idiopatske Parkinsonove bolezni in pri 16 patološko potrjenih primerih sindroma Steele-Richardson-Olszewski (SROS). Na pet kliničnih značilnosti odprta verjetnostna skala je dobro ločila zgodnjo čisto parkinsonsko obliko MSA od začetne Parkinsonove bolezni, ne pa od SROS. Vendar pa so bolniki s SROS pogosto imeli dodatne klinične znake, ki so jih razlikovali od bolnikov s Parkinsnovo boleznijo.
Descriptors		PARKINSON DISEASE PARKINSON DISEASE, SYMPTOMATIC SUPRANUCLEAR PALSY, PROGRESSIVE RETROSPECTIVE STUDIES MIDDLE AGE AGED