Author/Editor		Poungvarin, N; Devahastin, V
Title		An experience of 800 patients with various movement disorders treated with botulinum A toxin injection
Translated title		Botulin pri zdravljenju 800 bolnikov z raznimi motnjami gibov
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 65, št. Suppl 3
Publication year		1996
Volume		str. III-89-92
Language		eng
Abstract		Results of a prospective open study of botulinum toxin A treatment in various movement disorders at Sitiraj Hospital, Mahidol University are presented and discussed. Included were 800 patients: a) 543 patients (68%) with hemifacial spasm; b) 77 patients (10%) with occupational cramp; c) 68 patients (9%) with blepharospasm and Meige syndrome; d) 60 patients (8%) with spasmodic torticollis; e) 17 patients (2%) with hemidystonia and generalised dystonia; f) 11 patients (1%) with spasmodic dysphonia; g) 7 patients (1%) with spastic hemiparesis; and h) 18 patients (2%) with miscellanous movement disorders (i.e. tics, Gilles de la Tourette, facial myokimia, benign fasciculation, etc.). Outcome of treatment for hemifacial spasm was excellent in 442 patients (82%), moderate in 55 patients (10%), mild in 38 patients (7%), and 7 patients (1%) showed no improvement or deterioration. Mild transient facial weakness occurred in 50 patients (9%) and mild ptosis in 12 patients (2%) after the treatment. The beneficial effect of botulinum toxin treatment lasted 3-6 months. Twothirds of patients with occupational cramp and spasmodic torticollis, and 75-85% of those with blepharospasm, spasmodic dysphonia, spastic hemiparesis, and tics showed good response. In conclusion, Botulinum toxin A is a simple, safe, and effective but expensive out-patient treatment for patients with various kinds of movement disorders.
Summary		Predstavljamo rezultate odprte prospektivne študije učinka botulina A pri različnih ekstrapiramidnih boleznih. Študija zajema 800 bolnikov: 542 (68%) s hemifacialnim spazmom, 77 (10%) s "poklicnimi" distonijami, 68 (9%) z blefarospazmom in sindromom Meige, 60 (8%) s spazmodičnim tortikolisom, 17 (2%) s hemidistonijo in generalizirano distonijo in 18 (2%) z drugimi ekstrapiramidnimi motnjami (npr. tiki, sindromom Gilles de la Tourette, facialno miokimijo, benignimi fasciulacijami...). Uspeh zdravljenja hemifacialnega spazma je bil odličen pri 442 bolnikih (82%), zmeren pri 55 (10%), blag pri 38 (7%), pri 7 bolnikih (1%) pa ni bilo nikakršnega izboljšanja ali pa se je stanje celo poslabšalo. Po zdravljenju se je pojavila blaga prehodna oslabelost obraznih mišic pri 50 bolnikih (9%), blaga ptoza pa pri 12 (2%). Izboljšanje je trajalo 3-6 mesecev. Dober odziv smo opazovali tudi pri 2/3 bolnikov s "poklicnimi" distonijami in pri 75-85% bolnikov s blefarospazmom, spazmodično disfonijo, spastično hemiparezo in tiki. Ambulantno zdravljenje različnih motenj gibanja z botulinom je torej preprosto, varno in učinkovito, vendar drago.
Descriptors		SPASM DYSTONIA BOTULINUM TOXINS RETROSPECTIVE STUDIES THAILAND