Author/Editor		Holzmuller, P; Moser, E; Werba, A; Markis, EM; Gomišček, G
Title		In vitro NMR investigation of controlled single and repeated isoflurane anesthesia
Type		članek
Source		Magn Reson Med
Vol. and No.		Letnik 10, št. 3
Publication year		1992
Volume		str. 393-400
Language		eng
Abstract		Immobilization of laboratory animals is a basic requirement for experimental in vivo NMR measurements. The effect of single and repeated isoflurane anesthesia on proton NMR relaxation times T1 and T2 in rat liver was studied. Furthermore, physiological monitoring was performed to evaluate the influence of isoflurane anesthesia (up to 2 hr) on biological parameters. Neither single nor repeated isoflurane application over the observed time produce relevant alterations of physiological parameters or relaxation times, compared with untreated control groups. Therefore, we conclude that isoflurane anesthesia is appropriate for in vivo NMR investigations, especially of the liver.
Descriptors		ANESTHESIA ISOFLURANE NUCLEAR MAGNETIC RESONANCE RESPIRATION CARBON DIOXIDE HEMODYNAMICS ISOFLURANE LIVER RATS RATS, INBRED STRAINS