Author/Editor     Devilee, P; Hermans, J; Eyfjord, J; Boorresen, AL; Liderau, R; Sobol, H; Borg, A; Cleton-Jansen, AM; Olah, E; Peterlin, B
Title     Loss of heterozygosity at 7q31 in breast cancer: results from an International collaborative study group
Type     članek
Source     Genes Chromosomes Cancer
Vol. and No.     Letnik 18, št. 3
Publication year     1997
Volume     str. 193-9
ISSN     1045-2257
Language     eng
Abstract     Loss of heterozygosity (LOH) at 7q31 has been claimed to occur in over 80 percent of all breast cancers and to be of prognostic significance. This would make this genetic alteration the most common event observed in breast cancer to date. Others, however, have been unable to confirm this high incidence. In this multicenter study, we have complied LOH scorings for three polymorphic markers for 7q31-q32 in 683 breast tumors. Although some significant differences between centers existed, no center reported more than 40 percent LOH, and the average rate was 19 percent. Disease-free and overall survival of the patients whose tumors carried LOH at 7q31 did not differ significantly from those patients whose tumors showed retention of heterozygosity at 7q31. In a double-blind scoring of a subset of the raw data, an average discordant rate of LOH scoring of 12 percent was observed. While startling in itself, this was unable to explain the variation among centers, nor the difference with the initially reported high rate of LOH. We conclude that LOH at 7q31 is not important as a genetic alteration in breast cancer as originally suggested, nor a strong determinant of disease outcome.
Descriptors     BREAST NEOPLASMS
CHROMOSOME ABERRATIONS
CHROMOSOMES, HUMAN, PAIR 7
HETEROZYGOTE
DNA, NEOPLASM
EUROPE
MICROSATELLITE REPEATS
PROGNOSIS
SURVIVAL ANALYSIS