Author/Editor		Čižman, Milan; Paragi, Metka; Jovan-Kuhar, Nadja; Gubina, Marija; Oražem, Andreja; Pokorn, Marko; et al, ;
Title		Antimicrobial resistance of invasive streptococcus pneumoniae in Slovenia, 1993-1995
Type		članek
Source		Scand J Infect Dis
Vol. and No.		Letnik 29
Publication year		1997
Volume		str. 251-4
Language		eng
Abstract		The susceptibility of 108 Streptococcus pneumoniae strains isolated from normally sterile body sites during 1993-1995 in Slovenia has been studied. Overall resistance to penicillin, erythromycin, trimethoprim-sulfamethoxazole, cefuroxime, cefaclor and chloramphenicol was 16.6, 0.9, 28.8, 0, 4.5 and 4.6%, respectively. All penicillin-resistant isolates (intermediate resitance) were susceptible to cefotaxime, ceftriaxone and vancomycin. Isolates less suceptible to penicillin were also significantly less sensitive to chloramphenicol, cefaclor and trimethoprim-sulfamethoxazole than penicillin-sensitive strains. Pneumococci isolated in children were significantly (p < 0.05) more resistant to trimethoprim-sulfamethoxazole than those isolated in adults. The study demonstrated moderate resistance rate of S. pneumoniae to penicillin and trimethoprim-sulfamethoxazole and a low-level resistance rate to erythromycin, cefaclor and chloramphenicol. No straightforwad correlation between overall consumption of antibiotics and antimicrobial resistance was found.
Descriptors		DRUG RESISTANCE, MICROBIAL PENICILLIN RESISTANCE PNEUMOCOCCAL INFECTIONS STREPTOCOCCUS PNEUMONIAE ANTI-INFECTIVE AGENTS CEPHALOSPORINS CHLORAMPHENICOL DRUG RESISTANCE, MULTIPLE MICROBIAL SENSITIVITY TESTS SEROTYPING SLOVENIA TRIMETHOPRIM-SULFAMETHOXAZOLE COMBINATION