Author/Editor		Ivanuša, Marijan
Title		Cisaprid - sodobni gastrointestinalni prokinetik
Type		članek
Source		Krka Med Farm
Vol. and No.		Letnik 17, št. Suppl 1
Publication year		1996
Volume		str. 41-56
Language		slo
Abstract		Peristalsis plays an important role in the pathophysiology of the gastroesophageal reflux disease, gastroparesis and functional dyspepsia. The action of cisapride, mediated by the myenteric plexus, results in stimulation and co-ordination of the peristaltic wave of contraction. Owing to a special mechanism of action cisapride is associated with far less side effects than the older prokinetic agents. Cisapride increase the tone of the lower esophageal sphincter and improves esophageal peristalsis. This results in reduced frequency and duration of reflux episodes and, consequently, in shorter time periods when the esophageal pH value is within an acid range. The action of cisapride is not limited to the esophagus alone but also involves other parts of the gastrointestinal tract. It has been demonstrated that cisapride produces better co-ordination of the peristaltic wave of contraction between the gastric antrum and the duodenum, accelerates gastric emptying, and enhances motility of the large intestine. Metabolic interactions are possible with drugs which are metabolized at the cytochrome P450 subunit 3A4 in the liver. Cisapride is used for the treatment of the gastroesophageal reflux disease, gastroparesis, functional dyspepsia and in certain other conditions. The usual dose of cisapride is 40 mg daily for adult patients and 0.2 mg/kg body weight four times daily for children. Owing to its safety and efficacy profile casipride is considered a prokinetic agent of first choice for adult as well as pediatric patients.
Descriptors		GASTROESOPHAGEAL REFLUX ANTI-ULCER AGENTS PIPERIDINES