Author/Editor		Vogler, A; Meden-Vrtovec, H
Title		Insulin like growth factor-I in follicular fluid and serum in "low responders" undergoing IVF treatment
Type		članek
Source		In: Gomel V, Leung PCK, editors. In vitro fertilization and assisted reproduction. Proceedings of the 10th world congress of in vitro fertilization and assisted reproduction; 1997 May 24-28; Vancouver. Bologna: Monduzzi Editore,
Publication year		1997
Volume		str. 369-72
Language		eng
Abstract		The role of IGF-I in low ovarian response to ovarian stimulation by exogeneous gonadotrophin has not been clarified yet. Our study was designed as to evaluate the role of IGF-I in low ovarian response. Forty randomly selected "low-responders" (group "LOW") were compared with follicular fluid and serum IGF-I concentrations to 120 normal responding patients (group "NORMAL") in IVF treatment. Follicular fluid IGF-I concentration did not differ significantly between the two groups (235.27 micro g/l in group "LOW" and 233.48 micro g/l in group "NORMAL"; p < 0.05). The serum IGF-I concentration was significantly higher (343.74 micro g/l) in group "LOW" regarding the control group "NORMAL" (269.13 micro g/l; p < 0.05). Thus, we could propose that an elevated IGF-I level could represent an indicator of occult ovarian failure as well as an indicator of ovarian resistance for gonadotrophin stimulation in patients with normal basal FSH levels.
Descriptors		OVULATION INDUCTION INSULIN-LIKE GROWTH FACTOR I FSH ESTRADIOL GONADOTROPINS, CHORIONIC FERTILIZATION IN VITRO