Author/Editor		Rott, Tomaž; Kern, Izidor; Ferluga, Dušan
Title		Vloga patologije pri opredeljevanju kronične obstruktivne pljučne bolezni
Translated title		Role of pathology in chronic obstructive pulmonary disease
Type		članek
Source		In: Šorli J, editor. Zbornik predavanj Obravnava bolnika s KOPB (predlogi za nacionalna priporočila); 1997 jun 13-14; Portorož. Ljubljana: Pnevmološka sekcija Slovenskega zdravniškega društva,
Publication year		1997
Volume		str. 11-7
Language		slo
Abstract		Pulmonary emphysema (PE), chronic bronchitis (CB) and small airways disease (SAD) are nowadays included in chronic obstructive pulmonary disease (COPD). The diagnostic value of the bioptic specimens in patients with COPD is limited. The most common bronchial/ transbronchial bioptic tissue specimens obtained with fiberbronchoscopy are very small, often traumatized, and display many artifacts. Such material is usually unsatisfactory for the diagnosis of PE, and the evaluation of its type and size is impossible. Clinical data are the most relevant tor the diagnosis of CB. Small airways are often present in bioptic specimens. Thus, frequent non-specific and seldom relatively specific changes may be observed in SAD and many other diseases, including asthma, which may also cause airways obstruction, and should be considered in differential diagnosis of COPD. Better diagnostic yield of clinical, functional, laboratory etc. methods in these diseases demands thorough indication for the biopsy to be ethically justified and professionally rewarding. Ethical limits for biopsies in patients with COPD have also restrictive influence on research of etiopathogenesis and pathology with modern methodologies in human bioptic specimens.
Descriptors		LUNG DISEASES, OBSTRUCTIVE BIOPSY