Author/Editor		Pečovnik-Balon, Breda; Kolenc, Marija; Krajnc, Ivan
Title		The effect of calcitriol on secondary hyperparathyroidism in patients on hemodialysis
Type		članek
Source		In: Glassock RJ, Current therapy in nephrology and hypertension
Publication year		1992
Volume		str. 447-53
Language		eng
Abstract		In the past so called "trade-off hypothesis" has been accepted. According to this theory the secondary hyperparathyreoidism in renal failure is the consequence of the disturbed excretion of phosphate. Recent reseearch has revealed that the decreased secretion of 1.25(OH)2D3 vitamin-calcitriol also has a great influence upon it. In 1991 a study of the effect of 1.25(OH)2D3 vitamin on 13 patients suffering from terminal renal failure was carried out at the Maribor Teaching Hospital. The patients were of different ages and had been on hemodialysis for different periods of time. At the beginning of the treatment their levels of parathormone (PTHi) differed widely. A comparison of the group of patients treated with vitamin D to the control group receaving no vitamin D has been carried out. The criterions for therapy with calcitriol were: plesmic concentration of P, Ca, PxCa product. In the group of patient treated with no vitamin D after the 12 months therapy the level of PTH rose on average (from 210 ph/ml to 276 pg/ml). In the group of patients with calcitriol therapy plasmic concentration of parathormone has fallen (from 194 pg/ml to 104 pg/ml).
Descriptors		HEMODIALYSIS HYPERPARATHYROIDISM, SECONDARY CALCITRIOL KIDNEY FAILURE PARATHYROID HORMONES