Author/Editor		Rascol, O; Lees, AJ; Senard, JM; Pirtošek, Z; Montastruc, JL; Fuell, D
Title		Ropinirole in the treatment of levodopa-induced motor fluctuations in patients with Parkinson's disease
Type		članek
Source		Clin Neuropharmacol
Vol. and No.		Letnik 19, št. 3
Publication year		1996
Volume		str. 234-45
Language		eng
Abstract		Forty-six patients with Parkinson's disease experiencing motor fluctuations and not optimally controlled on levodopa received as adjunct therapy a new nonergoline dopamine agonist, ropinirole, in a 3-month randomized placebo-controlled trial. Ropinirole significantly reduced the duration of off periods as assessed by self-scoring diary cards. There were more nonserious dopaminergic adverse events in the ropinirole group. More patients withdrew because of adverse events or insufficient therapeutic effect in the placebo group. Ropinirole has beneficial adjuvant effects in parkinsonian patients with moderate motor disability and motor fluctuations.
Descriptors		ANTIPARKINSON AGENTS DOPAMINE AGONISTS INDOLES LEVODOPA PARKINSON DISEASE ADULT AGED DOUBLE-BLIND METHOD DRUG THERAPY, COMBINATION MIDDLE AGE MOTOR ACTIVITY