Author/Editor | Serša, Gregor; Čemažar, Maja; Menart, Viktor; Gaberc-Porekar, Vladka; Miklavčič, Damijan | |
Title | Anti-tumor effectiveness of electrochemotherapy with bleomycin is increased by TNF-alpha on SA-1 tumors in mice | |
Type | članek | |
Source | Cancer Lett | |
Vol. and No. | Letnik 116, št. 1 | |
Publication year | 1997 | |
Volume | str. 85-92 | |
Language | eng | |
Abstract | With the aim to increase anti-tumor effectiveness of electrochemotherapy, adjuvant immunotherapy with tumor necrosis factor-alpha (TNF-alpha) was tested on tumors in mice. Increased anti-tumor effectiveness on SA-1 tumors was observed after combining TNF-alpha, injected either intratumorally or peritumorally, with electrochemotherapy using suboptimal dose of bleomycin (BLM). The increased anti-tumor effectiveness was neither the result of potentiated anti-tumor effectiveness of TNF-alpha due to exposure of tumors to electric pulses, nor due to interaction with BLM. Therefore, the effect of adjuvant TNF-alpha treatment might be immunomodulatory, augmenting the anti-tumor activity of electrochemotherapy, and possibly adding a systemic component to the localized electrochemotherapy treatment. | |
Descriptors | BLEOMYCIN CHEMOTHERAPY, ADJUVANT ELECTROCHEMISTRY FIBROSARCOMA TUMOR NECROSIS FACTOR INJECTIONS, INTRALESIONAL MICE MICE, INBRED STRAINS NEOPLASM TRANSPLANTATION TUMOR CELLS, CULTURED |