Author/Editor     Serša, Gregor; Čemažar, Maja; Menart, Viktor; Gaberc-Porekar, Vladka; Miklavčič, Damijan
Title     Anti-tumor effectiveness of electrochemotherapy with bleomycin is increased by TNF-alpha on SA-1 tumors in mice
Type     članek
Source     Cancer Lett
Vol. and No.     Letnik 116, št. 1
Publication year     1997
Volume     str. 85-92
Language     eng
Abstract     With the aim to increase anti-tumor effectiveness of electrochemotherapy, adjuvant immunotherapy with tumor necrosis factor-alpha (TNF-alpha) was tested on tumors in mice. Increased anti-tumor effectiveness on SA-1 tumors was observed after combining TNF-alpha, injected either intratumorally or peritumorally, with electrochemotherapy using suboptimal dose of bleomycin (BLM). The increased anti-tumor effectiveness was neither the result of potentiated anti-tumor effectiveness of TNF-alpha due to exposure of tumors to electric pulses, nor due to interaction with BLM. Therefore, the effect of adjuvant TNF-alpha treatment might be immunomodulatory, augmenting the anti-tumor activity of electrochemotherapy, and possibly adding a systemic component to the localized electrochemotherapy treatment.
Descriptors     BLEOMYCIN
CHEMOTHERAPY, ADJUVANT
ELECTROCHEMISTRY
FIBROSARCOMA
TUMOR NECROSIS FACTOR
INJECTIONS, INTRALESIONAL
MICE
MICE, INBRED STRAINS
NEOPLASM TRANSPLANTATION
TUMOR CELLS, CULTURED