Author/Editor		Čižman, Milan; Paragi, Metka; Gubina, Marija; Jovan-Kuhar, Nadja; Pokorn, Marko; Kraigher, Alenka; Fišer, Jerneja; Kolman, Jana; Novak, Dušan; Drinovec, Bojan; et al, ;
Title		Epidemiologija invazivnih okužb s haemophilusom influenzae tip B pri otrocih v Sloveniji, 1993-1995
Translated title		Epidemiology of invasive Haemophilus influenzae type B disease in children in Slovenia, 1993-1995
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 66, št. 9
Publication year		1997
Volume		str. 469-72
Language		slo
Abstract		Background. Haemophilus influenzae type b is frequent cause of systemic infections in children under 5 years of age. Active immunization against Haemophilus influenzae is rountinely performed in many countries. A basic knowledge of epidemiology of these infections in Slovenia is necessary before introduction of vaccination. Patients and methods. Children aged 0 to 14 years with Haemophilus influenzae type b isolated from blood, CSF or other normally sterile body site in a period from January 1993 to December 1995 were included in a nationwide prospective study. Results. In a 3-year period, 56 invasive Hib infections were observed, representing 96.6% of all Haemophilus influenzae isolates. Meningitis was the most frequent clinical syndrome (68%), followed by pneumonia (12%), bacteremia/sepsis (7%) and other focal infections. The incidence of Hib disease in children under 5 years of age was 16.4/100,000, the incidence of Hib meningitis was 13.35/100,000 per year in the same age group. Mortality was 3.6%. Conclusions. Compared to developed countries a lower incidence of invasive Hib disease was observed in our 3-year study. The results obtained will provide a basis for an cost-benefit evaluation of potential benefits of Hib vaccination in Slovenia.
Summary		Izhodišča. Haemophilus influenzae tip b pogosto povzroča sistemske okužbe pri otrocih, mlajših od 5 let. pred uvedbo cepljenja proti bakteriji, ki je marsikje v svetu že rutinsko, je treba poznati osnovne epidemiološke podatke. Bolniki in metode. V prospektivno triletno študijo, ki je zajela vso Slovenijo, smo vključili otroke, stare o 0 do vključno 14 let, v obdobju od januarja 1993 do decembra 1995. Pri njih smo izolirali H. influenzae tip b iz krvi, možganske tekočine ali druge, sicer sterilne telesne tekočine. Rezultati. V triletnem obdobju smo dokazali 56 invazivnih okužb, ki jih je povzročil H. influenzae tip b, kar predstravlja 96,6% vseh izolatov H. influenzae. od kliničnih sindromov smo najpogosteje ugotovili meningitis (68%), sledijo pljučnica (12%), bakteriemija/sepsa (7%) in v posameznih primerih še druge žariščne okužbe. Letna incidenca je bila pri otrocih pod 5 leti starosti 16,4 na 100.000 otrok, incidenca meningitisa pa 13,35 na 100.000 otrok v isti starostni skupini. Smrtnost je bila 3,6%. Zaključki. S triletno študijo smo ugotovili nižjo incidenco invazivnih okužb s H. influenzae tip b v primerjavi s študijami v drugih razvitih državah. Rezultati nam bodo osnova za izračun ekonomske upravičenosti cepljenja v Sloveniji.
Descriptors		HAEMOPHILUS INFECTIONS HAEMOPHILUS INFLUENZAE INCIDENCE CHILD SLOVENIA