Author/Editor		Trontelj, JV; Fernandez, JM; Mihelin, M; Rugelj, D
Title		The function of neuromuscular junction in upper motor neuron weakness
Type		članek
Source		In: Pedotti A, Ferrarin M, Quintern J, et al, editors. Neuroprosthetics from basic research to clinical application. Biomedical and health research program (BIOMED) of the European union. Concerted action: restoration of muscle activity through FES and associated technology (RAFT). Berlin: Springer,
Publication year		1996
Volume		str. 129-35
Language		eng
Abstract		Hemiplegic muscles often show abnormally fast fatigue when stimulated through their nerves. Single fibre EMG with axonal microstimulation was used to examine the possible contribution of neuromuscular transmission impairment. The study was performed in normal and paralysed limbs of 24 hemiparetic patients with a recent ischemic stroke. The mean jitter values were mildly but definitely abnormal on the affected side in 18 patients, suggesting some degree of transsynaptic lower motor neuron dysfunction during early stages of upper motor neuron paralysis. This degree of impairment, however, does not seem to play any significant role in the abnormal fatigue of muscles affected with upper motor neurone weakness.
Descriptors		HEMIPLEGIA ELECTROMYOGRAPHY MUSCLE FIBERS MUSCLE FATIGUE NEUROMUSCULAR JUNCTION CEREBROVASCULAR DISORDERS