Author/Editor		Zidar, Nina
Title		Vpliv znotrajmaterničnega zastoja rasti na potek ledvičnih bolezni
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		1997
Volume		str. 56
Language		slo
Abstract		The purpose of our studies was to determine whether intrauterine growth retardation (IUGR), defined as birthweight below the 10th percentile for gestational age, has any effect on the clinical course and prognosis of renal diseases. Our first study included 50 children with biopsy proven IgA glomerulonephritis (IgA GN), who were followed for at least 3 years and in whom birthweights and gestational ages were available. Six of the 50 children (12 %) had signs of IUGR at birth with a birthweight below the 10th percentile for gestational age. There were no significant diferences in initial clinical presentation between children with IUGR and children without IUGR. However, in kidney biopsy specimens, glomerulosclerosis was more frequent (p = 0.058) and more severe (p < 0.015) in children with IUGR than in children without IUGR. Furthermore, at the end of the follow-up period, we observed a significantly higher incidence of arterial hypertension (p < 0.05) in children with IUGR than in children without IUGR. As arterial hypertension and glomerulosclerosis are among the most important factors in the progression of renal diseases, a higher incidence of renal failure could probably be expected in children with IUGR in the future. Our results indicate that children with IgA GN who had suffered from IUGR, are at higher risk of progressive course than those without ILTGR. Our second study included 40 children with idiopathic nephrotic syndrome with minimal changes (NSMC), who were followed for at least 3 years and in whom birthweights and gestational ages were available. Five of the 40 children (12.5 %) had had signs of IUGR at birth with a birthweight below the 10th percentile for gestational age. In children with IUGR, we observed a significantly higher incidence of relapses (p < 0.001) and a higher incidence of steroid dependency (p = 0.015). (Abstract truncated at 2000 character)
Descriptors		FETAL GROWTH RETARDATION KIDNEY DISEASES CHILD GESTATIONAL AGE INFANT, SMALL FOR GESTATIONAL AGE INFANT, NEWBORN BIOPSY GLOMERULONEPHRITIS, IGA GLOMERULOSCLEROSIS, FOCAL NEPHROTIC SYNDROME HYPERTENSION PROGNOSIS