Author/Editor		Tul, Nataša
Title		Napovedna vrednost lažno pozitivnega trojnega hormonskega testa za zaplete v nosečnosti
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		1997
Volume		str. 56
Language		slo
Abstract		Backgraund: Down syndrome (DS) has been recognized the most frequent individual cause of mental retardation in children. Approximately 1/1000 liveborn babies is affectred by it. The detection of women, pregnant with a baby affected by DS, has been done with a screening, based on maternal age. This type of screening has proved unsatisfactory, as in Slovenia in the period 1987-1994 only 17% of fetuses affected by DS were detected. In 1995 the second trimester screening based on the triple hormonal test (THT) was introduced. It is estimated that yearly approximately 60% of fetuses, affected by DS, will be detected, and that there will be 5-7% false positive results. The aim of this study was to find whether the pregnant women, enrolled in the group at high risk for delivering a baby with DS because of false positive results, there exists a higher incidence of various pregnancy-induced complications, by comparing the course of pregnancy and its outcome in the groups of women with false positive and true negative results. Methods: In the period August 1995 - October 1996, 675 pregnant women were enrolled in the prospective value of THT. Of the 675 pregnant women, 38 (5,6%) had false positive THT results. To each women enrolled in the study group (false positive results) two controls with a true negative result were found. Two additional criteria were maternal age +- 1 year and gestational age +- 1 week. To 7 study group women aged > 37 years the appropriate controls could not be found. Thus, the study group consisted of 31, and the control group of 62 women. To obtain the data on the course and outcome of pregnancy, the labour and neonatal respective records were analyzed. The gorups were compared using the Chi-square test, the differences being determined as statistically significant at the p<0,05. The correlation between the hormonal values and pregnancy-induced complications was evaluated using the logistic regression model. (Abstract truncated at 2000 characters).
Descriptors		DOWN SYNDROME ALPHA-FETOPROTEINS ESTRIOL GONADOTROPINS, CHORIONIC FALSE POSITIVE REACTIONS PREGNANCY INFANT, NEWBORN PRENATAL DIAGNOSIS MATERNAL AGE PREGNANCY, HIGH-RISK GESTATIONAL AGE LABOR, PREMATURE PREGNANCY COMPLICATIONS KARYOTYPING