Author/Editor     Paro-Panjan, Darja
Title     Potek in prognoza krčev v novorojenčkovem obdobju
Type     monografija
Place     Ljubljana
Publisher     Medicinska fakulteta
Publication year     1997
Volume     str. 62
Language     slo
Abstract     Starting-point and aim of the research: Neonatal convusions occur frequently and are the most distinctive sign of neurological disease or disturbance of the central nervous system The outcome is, to a large extent, dependent on the cause of the convulsions, while some other clinical and electrophysiological parameters are also predictive. The aim of the research was to obtain insight into the characteristics of neonatal convulsions in our situation, verify the significance of etiology and assess the value of various parameters (age at first seizure, number of days with seizures, neonatal neurological examination and electroencephalogram) for predicting the final outcome. Subjects and methods: The subjects were 61 neonates, who were hospitalized on the Neonatal Department of the Children's Hospital between 1.1.1989 - 31.12.1995. Medical records were reviewed to determine the neonatal neurological state and to classify the electroencephalographic (EEG) recordings. The etiology was determined on the basis of history, clinical course and results of laboratory and radiological investigations. The children underwent follow-up neurological examination, psychometric testing and assessment as regards seizures at the age of 1.5-7 years. Potential predictive factors were determined by analyzing the relationship between all parameters and the outcome with regard to signs of neurological damage, epilepsy and psychomotor retardation. For each potential predictive factor the relative risk for outcome was determined using the univariate binary logistic regression method. The independent predictive value of individual parameters was assessed by the multivariate binary logistic regression method. Results. The most important cause of convulsions was hypoxia (25%), the most frequent clinical type of seizures multifocal clonic seizyres (46%). In 73% of children the seizures occurred in the first 72 hours of life, in 67% they lasted less than 5 days.Abstract trunc at 2000 charaters.
Descriptors     SPASMS, INFANTILE
INFANT
INFANT, NEWBORN
CHILD
ELECTROENCEPHALOGRAPHY
MEDICAL HISTORY TAKING
NEUROLOGIC EXAMINATION
PSYCHOLOGICAL TESTS
PSYCHOMOTOR PERFORMANCE
MENTAL RETARDATION
PROGNOSIS