Author/Editor		Stegnar, Mojca; Ogrinc, Katarina; Mihalek, Petra; Peternel, Polona
Title		Laboratorijski nadzor zdravljenja s kumarini: kako zanesljivo je mednarodno usmerjeno razmerje (INR)?
Translated title		Laboratory monitoring of coumarin treatment: how reliable is the international normalized ratio (INR)?
Type		članek
Source		Farm Vestn
Vol. and No.		Letnik 48, št. 1-2
Publication year		1997
Volume		str. 107-11
Language		slo
Abstract		Anticoagulant treatment with coumarins is monitored with a laboratory test - prothorombin time. Results of this test are expressed in international normalized ratio (INR), which is supposed to give comparable values in spite of the use of thromboplastins with various sensitivity. With the use it became apparent that INR did not fullfill the expectation completely, because it is influenced by various factors such as sensitivity of tromboplastin and use of coagulation instruments. The authors describe reliability of INR at the onset of anticoagulant treatment, reliability when using less sensitive thromboplastins, changes of INR due to use of different coagulation instruments and how incorrect INR values are obtained. They describe the therapeutic control of anticoagulant treatment and their own results on comparison of INR in patients on coumarins. The authors conclude that in spite of certain disadvantages. INR is the only reliable solution curently available for reporting results of prothrombin time.
Summary		Antikoagulacijsko zdravljenje s kumarini spremljamo z laboratorijsko preiskavo - protrombinskim časom. Rezulate te preiskave izražamo z mednarodnim umerjenim razmerjem (International Normalized Ratio = INR), s katerim naj bi dobili primerljive rezulate kljub uporabi različno občutljivih reagentov (tromboplastinov). Z večletno uporabo INR se je izkazalo, da tak način izražanja rezultatov ni popolnoma izpolnil pričakovanj, saj nanj še vedno vplivajo različni dejavniki, kot so npr. občutljivosti tromboplastina in uporaba različnih koagulacijskih aparatov. Avtorice opisujejo zanesljivost INR ob uvajanju antikoagulacijskega zdravljenja, zanesljivost pri uporabi neobčutljivih tromboplastinov, spremembe INR zaradi uporabe različnih koagulacijskih aparatov ter kako pride do napačno izračunanih INR. Opisujejo tudi celostno kontrolo antikoagulacijskega zdravljenja ter lastne rezulate o primerljivosti INR pri nadzoru bolnikov na kumarinih. Avtorice zaključujejo, da je INR kljub pomanjklivostim za enkrat edini zanesljivi način izražanja rezultatov protrombinskega časa.
Descriptors		COUMARINS PROTHROMBIN TIME THROMBOPLASTIN QUALITY CONTROL