Author/Editor		Križman, Igor; Ribnikar, Mojca; Kozjek, Franc; Primožič, Stane
Title		Comparative amoxicillin - azythromycin treatment of Helicobacter pylori positive patients with bleeding duodenal ulcer
Type		članek
Source		Acta Pharm Zagreb
Vol. and No.		Letnik 47, št. 3
Publication year		1997
Volume		str. 183-8
Language		eng
Abstract		Our study was focused on the assessment of duodenal ulcer healing and eradication of Helicobacter pylori as well as on the recurrence rate of duodenal ulcer bleeding in a group of 53 patients with H. pylori. All the patients had previous hemorrhage from the ulcer which had been successfully stopped by sclerotherapy. The patients were randomised into two therapeutic groups. The first group (n = 36) was treated with a combination of omeprazole and amoxicillin and the second group (n = 17) with omeprazole and azithromycin. The criteria for successful eradication of H. pylori were negative rapid ureas tests and negative histology on H. pylori four weeks after the treatment. Eradication of H. pylori was achieved in 25 (69%) patients from the first group and in 8 patients (47%) from the second group. No maintenance treatment was applied to the patients with successful eradication of H. pylori. The patients, in whom the eradication of H. pylori failed, the maintenance therapy with 150 mg of ranitidine daily, was given. The patients were monitored for various periods of time, altogether for 926 months. Only one hemorrhage was observed 23 months after entering the study. The patient was from the second group with an unsuccessful eradication of H. pylori. By eradicating H. pylori, the incidence of relapse of ulcer bleeding in the bulbus of the duodenum in H. pylori positive patients is reduced from 25-40% to 0 to 3% (1). Unfortunately, there is no simple means of eradicating the H. pylori infection. A wide variety of combinations has been used with different success (2). Amoxicillin, tetracycline, metronidazole and clarithromycin are most frequently used as antibiotics, and omeprazole as a proton pump inhibitor (3,4). (Abstract truncated at 2000 characters.)
Descriptors		DUODENAL ULCER PEPTIC ULCER HEMORRHAGE AMOXICILLIN AZITHROMYCIN HELICOBACTER PYLORI