| Author/Editor | Omejc, Mirko | |
| Title | Prognostični pomen DNA anevploidije pri raku želodca | |
| Translated title | Prognostic significance of DNA aneuploidy in gastric cancer | |
| Type | monografija | |
| Place | Ljubljana | |
| Publisher | Medicinska fakulteta | |
| Publication year | 1996 | |
| Volume | str. 68 | |
| Language | slo | |
| Abstract | We analyzed the DNA ploidy of 76 gastric cancers using flow cytometry on paraffinembedded material in patients having a potentially curative (RO) resection with D2 lymphadenectomy. The prognostic significance of DNA aneuploidy was compared with that of conventional histological grading and staging of the tumor (TNM stage, grading, type of tumor according to Lauren's, Ming's, WHO and Borrmann's classification). DNA aneuploidy was found in 39 cases (51%), 37 (49%) were diploid. Intestinal type of tumor was observed in 37 cases (49%), diffuse type in 27 (36%) and mixed type in 12 (15%) cases. There was no significant difference in frequency of DNA aneuploidy in terms of depth of tumor infiltration (pT), lymph node involvement (pN), grade (G), Borrmann's type, localization of the primary tumor and histological type according to Ming's and WHO classification. Tumors of intestinal type and tumors found in older patients ( > 50 years) were significantly more frequently DNA aneuploid than tumors of diffuse type or tumors found in younger patients ( < 50 years), what is an evidence in favor of Lauren's distinguishing of two different pathogenetic types of gastric cancer. Determination of DNA ploidy of the primary tumor appears to be of limited prognostic value in patients with resectable gastric cancer. We didn't find a significant difference in survival of patients with DNA aneuploid tumors when compared to DNA diploid tumors, though the prognosis of the patients with lower DNA index (DI < 1,2) tended to be better than that of higher DNA index (DI > 1,2), but the difference didn't reach a statistically significant level (p = 0,09). Independent prognostic factors found in our analysis were depth of tumor infiltration (pT) and lymph node involvement (pN) at the time of resection. | |
| Descriptors | STOMACH NEOPLASMS ANEUPLOIDY PROGNOSIS FLOW CYTOMETRY DNA SURVIVAL ANALYSIS GASTRECTOMY LYMPH NODE EXCISION NEOPLASM STAGING SEX FACTORS AGE FACTORS |