Author/Editor		Koren, Srečko; Poljak, Mario
Title		Molekularna biologija in patogenetski mehanizmi virusa človeške imunske pomanjkljivosti
Translated title		Molecular biology and pathogenetic mechanisms of the human immunodeficiency virus
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 36, št. Suppl
Publication year		1997
Volume		str. 47-58
Language		slo
Abstract		The human immunodeficiency virus (HIV), the etiologic agent of acquired immunodeficiency syndrome (aids) elicits a progressive and profound immunosuppression through a depletion of helper CD4+ T lymphocytes. This review focuses on the molecular aspects of HIV genome organization, virion structure and replication. The structural, regulatory and accessory proteins of HIV are discussed in terms of their multifunctional role in virus replication and pathogenicity. The potential mechanisms by which HIV causes destruction or dysfunction of T lymphocytes and macrophages are also briefly summarized.
Summary		Virus človeške imunske pomanjkljivosti (HIV), povzročitelj sindroma pridobljene imunske pomanjkljivosti (aidsa), sproži množično uničenje pomočniških limfocitov T CD4+, zaradi česar pride do napredujoče, obsežne oslabitve imunskega sistema. Pričujoči pregledni članek obravnava molekularno zgradbo in razmnoževanje HIV Prikazana je tudi vloga virusnih strukturnih, regulatornih in akcesornih beljakovin pri razmnoževanju in patogenosti virusa. Na koncu je navedenih nekaj možnih patogenetskih mehanizmov, s pomočjo katerih HIV uničuje ali ovira delovanje limfocitov T in makrofagov.
Descriptors		HIV GENOME, VIRAL VIRION VIRUS REPLICATION MOLECULAR BIOLOGY