Author/Editor		Godić, Dobrivoje
Title		The distribution of chlorinated pesticides in mother's serum and milk as well as in the serum of their new-born children in the region of Prekmurje - Slovenia
Translated title		Distribucija kloriranih pesticidov v materinem serumu in mleku ter serumu novorojenčkov v regiji Prekmurje
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 66, št. 12
Publication year		1997
Volume		str. 615-8
Language		eng
Abstract		Background. The research aimed to determine the serum concentrations of organochlorine pesticides in the following women in childbed, and mothers thirty days after childbirth, newborns and 30-day-olds and mother's milk. A further objective was to study the connections between the above. The study involved 40 randomly selected mothers and their children from the region called Prekmurje. Methods and results. The analyses were carried out by gas chromatograhy. Medium concentration levels of pesticides in women in childbed varied a lot; the highest were the lewels of ppDDT and ppDDE and a little bit lower those of HCB, opDDT, lindane, alpha-HCH and ppDDD. When comparing the serum concentrations of pesticides in the women in childbed and in their new-born children, it was established the medium levels of HCB and opDDT were higher in children than in their mothers. There was a signifficant positive ling between the serum concentrations of pesticides in the women in childbed and in the umbilical cord, which is especially true for HCB, ppDDD and HCH. The comparison between the serum concentrations of pesticides in the women in childbed and in the same women 30 days after childbirth proved that 30 later the concentrations of pesticides were lower, with the exception of ppDDD. There was also a sharp drop in the concentrations of DDE. A significant positive link was also evident between serum concentrations of HCB in mothers on the 30th day after childbirth and in their 30-day-old children.
Summary		Izhodišča. Posebno vprašanje pri kontaminaciji človeka in njegovega okolja predstavljajo pesticidi iz klorove skupine derivatov ogljikovodika - tako imenovani klorirani ogljikovodiki. Le-ti se po resorpciji iz prebavnega trakta, pljuč ali kože večinoma odlagajo v maščobnem tkivu človeka. Pomembna pot izločanja je prek posteljice in humanega mleka. Cilj raziskovanja je bil ugotoviti koncentracijo kloriranih pesticidov v naslednjih kategorijah: - v serumu porodnice in 30 dni pozneje, - v serumu novorojenčka ob rojstvu in 30 dni pozneje, - v materinem mleku, ter ugotoviti njihovo medsebojno povezanost. Metode in rezultati. Analiza je bila opravljena pri 40 parih mati-otrok iz Prekmurja z metodo naključnega izbora in s plinsko kromatografijo. Povprečne vrednosti koncentracije pesticidov v serumu porodnic so različne; največje so za ppDDT1 (1,18 ng/ml) in ppDDE2 (0,90 ng/ml), sledijo HCB3 (0,72 ng/ml), opDDT4 (0,38 ng/ml), lindan5 (0,24 ng/ml), alpha-HCH6 (80,09 ng/ml) in ppDDD7 (0,002 ng/ml). Če primerjamo koncentracijo pesticidov v serumu porodnic in novorojenčkov, ugotovimo, da so srednje vrednosti koncentracij HCB (1,95 ng/ml) v serumu novorojenčkov višje od tistih v serumu porodnic. Podobno je pri koncentracijah ppDDT (1,02 ng/ml), medtem ko so koncentracije preostalih organoklorovih pesticidov v serumu novorojenčkov nižje kot pri porodnicah. Obstaja serum popkovine za HCB in ppDDD (p<0,001) in HCH (p<0,01). Pri primerjavi koncentracije pesticidov v serumu porodnic in 30 dni po porodu ugotovimo, da so padle koncentracije vseh, razen ppDDD. Bistveno nižje so koncentracije DDE (p<0,05). Med koncentracijo v serumu mater 30 dni po porodu in otrok 30 dni po porodu je pomembna pozitivna odvisnost pri HCB (p<0,001). Kljub velikim koncentracijam v mleku imajo matere okrog 30. dneva laktacije bistveno nižjo koncentracijo kot ob porodu - z izjemo lindana. Pojav razlagamo z znatnim prehodom pesticidov v mleku in hitrim odlaganjem v maščobno tkivo. (Abstract trunc. at 2000 ch.)
Descriptors		HYDROCARBONS, CHLORINATED MILK, HUMAN INFANT, NEWBORN CHROMATOGRAPHY, GAS