Author/Editor | Huebner, Ralf-Harto; Bohuslavizki, Karl H; Brenner, Winfried; Klutmann, Susanne; Feyerabend, Bernd; Luettges, Jutta; Tinnemeyer, Stephan; Mester, Janos; Clausen, Malte; Henze, Eberhard | |
Title | Radioprotection of salivary glands by amifostine in high-dose radioiodine therapy investigated in a new rabbit animal model | |
Type | članek | |
Source | Radiol Oncol | |
Vol. and No. | Letnik 31, št. 3 | |
Publication year | 1997 | |
Volume | str. 279-85 | |
Language | eng | |
Abstract | Salivary gland damage following high-dose radioiodine treatment (HD-RIT) is a well known side effect. Since differentiated thyroid cancer (DTC) has a very good prognosis, the reduction of long-term side effect is of major interest. Therefore, the radioprotective effect of amifostine was investigated in a rabbit animal model. Quantitative salivary gland scintigraphy was performed on 5 rabbits prior to and up to 3 months after HD-RIT applying 1 GBq I-131. The uptake of Tc-99cm-pertechnetate was calculated as a measure of parenchymal function. Three animals received 200 mg/kg amifostine prior to HD-RIT, and two served as controls. Salivary glands were examined histopathologically. In two control rabbits HD-RIT significantly (p<0.001) reduced pertechnetate uptake by 63% and 46% in parotid and submandibular glands, respectively, and lipomatosis was found histopathologically. In contrast, in three rabbits treated with amifostine parenchymal function was not decreased significantly (p=0.953), and lipomatosis was negligible. In conclusion, salivary gland impairment induced by HD-RIT can be evaluated quantitatively by salivary gland scintigraphy in rabbits, and amifostine significantly reduced salivary gland damage induced by HD-RIT. These encouraging results need furtner evaluation in patients since in may help to increase the quality of life of patients with diffentiated thyroid cancer. | |
Descriptors | SALIVARY GLANDS AMIFOSTINE RADIOTHERAPY RABBITS IODINE RADIOISOTOPES RADIATION-PROTECTIVE AGENTS |