Author/Editor		Borštnar, Simona; Čufer, Tanja; Rudolf, Zvonimir
Title		The urokinase-type plasminogen activator, its inhibitors and its receptor - the new prognostic factors in solid cancers
Type		članek
Source		Radiol Oncol
Vol. and No.		Letnik 31, št. 3
Publication year		1997
Volume		str. 298-304
Language		eng
Abstract		The urokinase-type plasminogen activator (uPA), its inhibitors (PAI-1 and PAI-2) and its receptor (uPAR) play nan important role in the degradation of the intercellular tissue, the process which affects the ability of cancer cells to invade to surrounding tissue and to metastasize. The results of clinical studies performed in the past few years point out a significant influence of uPA, PAI-1, PAI-2 and uPAR on the course of the disease and survival of patients with solid tumours, particularly breast cancer. Hopefully the categorization of patients according to the content of the serine proteases and its inhibitors in tumour tissues could provide a basis for more rational treatment planning and thus improving patients' survival.
Descriptors		NEOPLASMS UROKINASE SERINE PROTEINASE INHIBITORS SERINE PROTEINASES PROGNOSIS