Author/Editor		Eržen, Janez; Kocijančič, Andreja; Jerman, Jože; Gantar-Rott, Urška; Rott, Tomaž
Title		Razmerje med težo nenormalnega obščitničnega tkiva, intaktnim parathormonom in serumskim kalcijem pri primarnem hiperparatiroidizmu
Translated title		The relationship between weight of abnormal parathyroid tissue, intact parathormone and serum calcium level in primary hyperparathyroidism
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 67, št. 1
Publication year		1998
Volume		str. 13-7
Language		slo
Abstract		Background. The purpose of this prospective study is to determine whether the relationship between the weight of parathyroid tissue, serum calcium (Ca) and parathyroid hormone (PTH) in patients with primary hyperparathyroidism (PHPT) can serve as a reliable parameter allowing for an accurate intraperative estimate of extent of parathyroid tissue to be removed. Methods. The study included 40 patients with symptomatic sporadic PHPT due to parathyroid adenoma or hyperplasia. Preoperative measurements of total and corrected serum calcium and intact parathyroid hormone (iPTH) levels were carried out in all patients. The weight (in mg) of parathyroid tissue removed at operation was determined. The drop in iPTH and calcium levels established after surgery clearly indicates the disorder was caussed by the removed parathyroid tissue mass. The regression correlation multivariate analysis showed that the weight of the removed tissue as an independent variable correlated with iPTH and calcium levels as dependent variables. Results. The amount of parathyroid tissue correlated strongly with iPTH (r = 0.549, p < 0.05), but rather poorly with serum calcium levels (r = 0.309). The parathyroid tissue weight: iPTH regression coeficient was 2.94, suggesting statistical significance (p < 0.05). Parathyroid tissue masses of equal weight were found to secrete varying levels of PTH, while equal calcium levels were found with varying weights of parathyroid tissue. In 28 patients with preoperative iPTH < 300 ng/l, this correlation was found to be more reliable. Their regression coeficient was 10.146, which implies that the parathyroid tissue weight increased significantly with the increas of iPTH by one unit (p < 0.05). Conclusions.(Abstract truncated at 2000 characters.)
Summary		Izhodišča. namen načrtovane študije je preverjanje zanesljivosti razmerja med težo obščitničnega tkiva pri primarnem hiperparatiroidizmu (PHPT) z vrdnostjo serumskega kalcija (Ca) in parathormona (PHT), na osnovi česar bi se med operacijo odločali o obsegu odstranitve obščitničnega tkiva. Metode. V študijo je bilo vključenih 40 bolnikov s simptomatskim sporadičnim PHPT, ki ga je povzročil adenom ali hiperplazija obščitničnih žlez. Pred operacijo je bila pri vseh določena vrednost celotnega in popravljenega kalcija v serumu ter intaktnega parathormona (iPTH). Pri operaciji je bilo odstranjeno obščitnično tkivo stehtano z miligramsko natančnostjo. Iz padca iPTH in koncentracijo kalcija se po operaciji lahko zanesljivo sklepa, da je znana gmota odstranjenega tkiva povzročala bolezen. Z regresijsko korelacijsko multivariantno analizo je prikazano razmerje med težo kot neodvisno spremenljivko in iPTH ter kalcijem kot odvisnima spremenljivkama. Rezultati. Značilna korelacija je med težo in iPTH (r = 0,549, p < 0,05) medtem ko je povezava med težo in kalcijem šibka (r = 0,309). Regresijski koeficient pri odnosu teža : iPTH je 2,94, kar je statistično pomembno (p < 0,05). Enake teže obščitničnega tkiva izločajo različne količine PTH, obenem pa so pri enaki vrednosti kalcija teže obščitničnega tkiva zelo različne. Zanesljivejša je bila korelacija pri 28 bolnikih, ki so imeli pred operacijo vrednosti iPTH < od 300 ng/l. Regresijski koeficient pri teh ej bil 10,146, kar pomeni statistično značilno povečanje teže pri porastu iPTH za eno enoto (p < 0,05). Zaključki. (Izvleček prekinjen pri 2000 znakih.)
Descriptors		HYPERPARATHYROIDISM PARATHYROID NEOPLASMS PARATHYROIDECTOMY PARATHYROID HORMONES CALCIUM