Author/Editor		Janež, Andrej; Mrevlje, Franc
Title		Insulinom z vidika kliničnih znakov, razpoznave in zdravljenja
Translated title		Insulinoma: clinical signs, diagnosis and treatment
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 67, št. 1
Publication year		1998
Volume		str. 19-22
Language		slo
Abstract		Background. Insulinomas are benign or malignant hormone secreting pancreatic tumours with a comparatively low prevalence. Benign tumours have an average diameter of 2.5 cm, while malignant ones measure over 3 cm. Methods. The tumour manifests itself clinically by signs of hypoglycaemia, which may be adrenergic or/and neuroglycopenic. The clinical picture varies widely and may be confused with variety of neurologic and psychiatric disorders. The diagnosis must be confirmed by laboratory tests demonstrating endogenous hyperinsulinism. The site of lesions is established by different investiations. Conclusions. The principal treatment is surgical removal. Inoperable tumours are managed by symptomatic therapy. Several drugs are known to be efective, but only diazoxide and octreotide, which prevent hypoglycaemia by inhibiting insulin release, are in widespread use.
Summary		Izhodišča. Sestavek zbirno obravnava insulinom kot benigni ali maligni hormonsko aktivni tumor pankreasa s posebnim ozirom na klinične znake, razpoznavo in zdravljenje. Insulinom se sorazmerno redko pojavlja. Benigni tumorji so povprečne velikosti do 2,5 cm, maligni pa presegajo 3 cm. Metode. Klinično se kaže z znaki hipoglikemije, ki so lahko adrenergični ali/in nevroglikopenični. Pestrost klinične slike lahko zavaja pri razpoznavi med nevrološkim in psihiatričnimi diagnozami. Insulinom je potrebno najprej laboratorijsko potrditi z dokazom endogenega hiperinsulinizma, nato pa s preiskovalnimi metodami določiti njegovo lokalizacijo. Zaključki. Temeljno zdravljenje insulinoma je kirurško, v inoperatibilnih primerih pa le simptomatsko. Znanih je več zdravil, uporabljata pa se le diazoksid in oktreotid, ki zavreta sproščanje insulina in s tem preprečujeta hipoglikemije.
Descriptors		INSULINOMA PANCREATIC NEOPLASMS HYPERINSULINISM HYPOGLYCEMIA