Author/Editor		Ghadially, Feroze N
Title		Pigments of the gatrointestinal tract. A saga of botched histochemistry.
Type		članek
Source		In: Rečnik A, Čeh M, Dražič G, editors. Proceedings of the 3rd multinational congress on electron microscopy; 1997 Oct 5-8; Portorož. Ljubljana: Slovenian society for electron microscopy,
Publication year		1997
Volume		str. 15-8
Language		eng
Abstract		It is now apparent that light microscopy (LM) and histochemistry had failed to correctly identify the nature and composition of pigments in various gastrointestinal tract (GI tract) melanoses. In most instances it was thought that the pigment was melanin or a melanin-like substance. Electron microscopy (EM) and electron-proge energy dispersive x-ray analysis (EDX) have rectified these errors and shown that: (1) in melanosis coli the pigment granules contatin lipofuscin: (2) in melanoses ilei the pigment granules may contain either silicates and titanium or hemosiderin; (3) in melanosis duodeni the pigment granules contain iron sulphide; and (4) in some cases of melanosis oesohagi the pigment granules contain melanin.
Descriptors		MELANOSIS GASTROINTESTINAL SYSTEM IMMUNOHISTOCHEMISTRY MICROSCOPY, ELECTRON ELECTRON PROBE MICROANALYSIS LIPOFUSCIN SILICATES TITANIUM HEMOSIDERIN IRON MELANINS