Author/Editor		Tomažič, J; Ihan, A; Strle, F; Cimperman, J; Stare, J; Matičič, M; Zakotnik, B
Title		Immunological differentiation between tickborne encephalitis with and without concomitant neuroborreliosis
Type		članek
Source		Eur J Clin Microbiol Infect Dis
Vol. and No.		Letnik 16, št. 12
Publication year		1997
Volume		str. 920-3
Language		eng
Abstract		Cerebrospinal fluid lymphocyte subsets in patients with tickborne encephalitis (TBE) and in patients with TBE with concomitant neuroborreliosis (double infection) were analysed by flow cytometry. Inthe TBE group, higher percentages of CD4+DR+ T cells (p = 0.02) and CD25+ T cells (p = 0.0002) were observed, while in the group with double infection, higher percentages of CD19+cells (p = 0.007), CD8+DR- T cells (p = 0.04), and CD3+CD71+ T cells (p = 0.0002) were found. It was concluded that several differences in immune cell parameters are present between the two groups of patients. Three variables (CD19+ cells, CD3+CD25+ T cells, CD3+CD71+ T cells) were included in the logistic regression model for calculation of probability for double infection. Flow cytometric characterisation of lymphocyte subsets in CSF can further substantiate the diagnosis of concomitant neuroborreliosis in patients with TBE.
Descriptors		LYME DISEASE BORRELIA BURGDORFERI ENCEPHALITIS, TICK-BORNE ENCEPHALITIS VIRUSES, TICK-BORNE CENTRAL NERVOUS SYSTEM CEREBROSPINAL FLUID LYMPHOCYTE COUNT T-LYMPHOCYTES LOGISTIC MODELS