Author/Editor | Miklavčič, D; Jarm, T; Čemažar, M; Serša, G; An, DJ; Belehradek, J Jr; Mir, LM | |
Title | Tumor treatment by direct electric current. Tumor perfusion changes | |
Type | članek | |
Source | Bioelectroch Bioener | |
Vol. and No. | Letnik 43 | |
Publication year | 1997 | |
Volume | str. 253-6 | |
Language | eng | |
Abstract | A single-shot electrotherapy with 0.6 mA direct current for 60 minutes delivered via two needle electrodes placed subcutaneously on opposite sides of a tumor induced statistically significant tumor growth delay in SA-1 and LPB murine fibrosarcoma tumor models. A prolonged vascular occlusion is indicated by the results of staining tumors with a Patent dye in the SA-1 tumor model immediately and 24 hours after one hour electrotherapy. The almost complete absence of tumor staining after treatment with electrotherapy in SA-1 tumors suggested that the tumor growth retardation could result from this prolonged vascular occlusion. However, statistically highly significant tumor growth delay in LPB tumors was accompanied by only aslight decrease of a tumor staining with Patent Blue. Thus, the observed effect of electrotherapy on both tumor growth retardation and perfusion in the LPB tumor model raises some doubt about the above hypothesis. | |
Descriptors | SARCOMA, EXPERIMENTAL ELECTRIC STIMULATION THERAPY MICE |