Author/Editor		Omejc, M; Repše, S; Bračko, M
Title		Evaluation of DNA ploidy in gastric carcinoma
Type		članek
Source		In: Siewert JR, Roder JD, editors. Progress in gastric cancer research 1997. Proceedings of the 2nd international gastric cancer congress; 1997 Apr 27-30; Munich. Bologna: Monduzzi editore,
Publication year		1997
Volume		str. 643-7
Language		eng
Abstract		In patients with gastric cancer who underwent a potentially curative (R0) resection with D2 lymphadenectomy (TNM stage I 27, II 11, III 38) DNA ploidy of tumor cells was determined and evaluated is relationship to conventional pathologic parameters, TNM stage and prognosis. DNA aneuploidy was foud in 39 cases (51%). No significant association between DNA aneuploidy and either patients' sex, tumor localization, pT, pN, histological or macroscopic type according to Ming or Borrmann was found. The incidence of DNA aneuploidy was significantly lower in tumors of diffuse type according to Lauren, in signet ring cell or undifferentiated type according to WHO, in poorly differentiated/undifferentiated tumors and in patients younger than 50 years. Alhough the 5-year survival rate of patients with lower DNA index tended to be better (DI<1.2 vs. DI>1.2, p=0.09), we coundn't find a significant correlation between DNA ploidy and prognosis.
Descriptors		STOMACH NEOPLASMS ANEUPLOIDY DNA FLOW CYTOMETRY NEOPLASM STAGING SURVIVAL ANALYSIS LYMPH NODE EXCISION