Author/Editor		Pernat, A; Pohar, B; Horvat, M
Title		Heart conduction disturbances and cardiovascular collapse after disopyramide and low-dose metoprolol in patient with hypertrophic obstructive cardiomyopathy
Type		članek
Source		J Electrocardiol
Vol. and No.		Letnik 30, št. 4
Publication year		1997
Volume		str. 341-4
Language		eng
Abstract		Disopyramide as an antiarrhythmic can be prescribed to patients with atrial fibrillation and, owing to its negative inototropic effect, to patients with hypertrophic obstructive cardiomyopathy. It is known that in patients with cardiac conduction disturances and heart failure, disoppyramide can adversely affect heart rhythm and conduction and induce cardovascular collapse. A patient with hypertrophic obstructive cardiomyopathy and paroxysms of atrial fibrillation is described who was treated with disopyramide and also, during the 5 days before admission, with metoprolol. In spite of normal cardiac conduction and function before disopyramide, this treatment was followed by hypotension, b radycardia, and cardiac conduction disturbances. Our case shows the potential for disopyramide, especially when combined with metoprolol, to induce grave adverse effects even in patients with normal cardiac conduction and ventricular function.
Descriptors		ARRHYTHMIA METOPROLOL DISOPYRAMIDE CARDIOMYOPATHY, HYPERTROPHIC ANTI-ARRHYTHMIA AGENTS ATRIAL FIBRILLATION DRUG INTERACTIONS DRUG THERAPY, COMBINATION ELECTROCARDIOGRAPHY SHOCK MIDDLE AGE