| Author/Editor | Beović, Bojana | |
| Title | Vpliv povišane telesne temperature pri človeku na različne farmakokinetične parametre nekaterih antibiotikov | |
| Type | monografija | |
| Place | Ljubljana | |
| Publisher | Medicinska fakulteta | |
| Publication year | 1997 | |
| Volume | str. 133 | |
| Language | slo | |
| Abstract | Background. Pharmacokinetics of antibiotics is influenced by many diseases and also physiological states. Fever is a complex response of the organism to external stimuli and some changes in the internal environment, manifesting itself by elevated body temperature and a number of systemic changes. Little is known about the influence of fever on pharmacokinetics of antibiotics. Data on the influence of fever on the pharmacokinetics of antibiotics in patients are especially scarce. Hypothesis and aim of the study. Fever is accompanied by numerous physiologic alterations, several of which have the potential to influence pharmacokinetics of antibiotics. Therefore, a prospective study was performed to determine the influence of fever on the pharmacokinetics of ciprofloxacin (CIP), penicillin G (PEN) and cefazoline (CEF) and to evaluate the pharmacodynamic importance of this influences. An estimation of influence of fever on pharmacokinetics and pharmacodynamics of antibiotics in different dosing regimens of CIP and PEN was performed as well. Design of the study. Prospective study with repetitive measurements. Patients. Acutely ill febrile (T axillary > 38,5 degree C) previously healthy adult patients, treated with CIP, PEN and CEF in short intravenous infusions were included in the study. The patients enrolled were hospitalized at the Department of Infectious Diseases in Ljubljana in the years 1991 to 1996. Methods. The serum samples were taken during the first dosing interval and during another dosing interval after defervescence. Serum CIP, PEN and CEF concentrations were determined by HPLC. Individual pharmacokinetic models were developed using analog and digital simulation tool. Computer simulation Simulink of the dosing regimen of 400 mg CIP tid and continuous intravenous infusion of PEN was performed using the same program package. Other pharmacokinetic parameters were calculated using PCNONLIN program package. (Abstract truncated at 2000 characters) | |
| Descriptors | ANTIBIOTICS FEVER COMPUTER SIMULATION CIPROFLOXACIN PENICILLIN G CEFAZOLIN INFUSIONS, INTRAVENOUS CHROMATOGRAPHY, HIGH PRESSURE LIQUID |